KDOQI (Kidney Disease Outcomes Quality Initiative)


NKF KDOQI GUIDELINES

Executive Summaries | Anemia | Hemodialysis | Peritoneal Dialysis |
Vascular Access | Nutrition | CKD 2002 | Dyslipidemias | Bone Metabolism | Hypertension and Antihypertensive Agents | Cardiovascular Disease in Dialysis Patients | History of KDOQI |

KDOQI Clinical Practice Guidelines for Cardiovascular Disease in Dialysis Patients


Work Group Biographies

Kline Bolton, MD, FACP, is Professor of Medicine at University of Virginia in Charlottesville, where he is Chief of the Division of Nephrology and Director of the Nephrology Clinical Research Center, Kidney Center and Renal Operations. He has received special honors from organizations ranging from the American Society for Clinical Investigation to the International Society of Nephrology. He has published many articles in journals ranging from American Journal of Kidney Diseases and Kidney International to Immunologic Renal Diseases, and contributed to numerous textbooks, including the Textbook of the Autoimmune Diseases and the Textbook of Nephrology. Dr. Bolton is Chairman of the Renal Physicians Association Work Group on Appropriate Preparation of Patients for Renal Replacement Therapy. In addition, Dr. Bolton serves on the Advisory Boards for Amgen and Ortho-Biotech. His research interests are in refining the epitope(s) involved in causing Goodpasture’s syndrome, treating glomerulonephritis, and disease management of CKD and ESRD.

Srinivasan Beddhu, MD, is Assistant Professor of Medicine at the University of Utah and Director, End-Stage Renal Disease Program, Salt Lake VA Healthcare System, Salt Lake City, UT. He received his medical degree from Madras University, Madras, India and completed his nephrology fellowship at the University of Pittsburgh, Pittsburgh, PA. His major area of research interest is atherosclerosis, inflammation and nutrition in chronic kidney disease. He has published several peer-reviewed articles in this area in journals such as the Journal of American Society of Nephrology, Kidney International, American Journal of Medicine and American Journal of Kidney Disease. He has received funding from several sources including the Agency for Healthcare Research and Quality (AHRQ). He has been a reviewer for many nephrology journals and reviewed abstracts for the American Society of Nephrology meetings. He is a member of the American Society of Nephrology, National Kidney Foundation, and International Society of Nephrology.

Vito M. Campese, MD, is Professor of Medicine, Physiology and Biophysics at the Keck School of Medicine, University of Southern California in Los Angeles, where he is Chief of the Division of Nephrology and Hypertension Center. Dr. Campese received his M.D. from the University of Bari in Italy. In 1974 he came to the United States via the University of Southern California for a fellowship in hypertension and was subsequently promoted to full Professor of Medicine with tenure in 1985. His main research interests are neurogenic factors in renal hypertension and salt-sensitivity in hypertension. He is the author or co-author of more than 235 scientific publications. Dr. Campese has been active in many professional societies, including the National Kidney Foundation, the American Society of Nephrology, and the American Society of Hypertension. He is a member of the Leadership Committee of the Council for High Blood Pressure. He has served or is serving on the editorial board of several renal and hypertension journals.

Blanche M. Chavers, MD, is Professor of Pediatrics at the University of Minnesota. She is a member of the American Society of Nephrology, the American Society of Pediatric Nephrology, the American Society of Transplantation, the International Society of Nephrology, and the International Society of Pediatric Nephrology. Dr. Chavers is Deputy Director of the Cardiovascular Special Studies Center at the United States Renal Data System, NIH. Dr. Chavers is on the Public Policy Committee of the American Society of Pediatric Nephrology, she is the American Society of Nephrology’s representative to UNOS, and she is a member of the American Society of Transplantation’s Kidney and Pancreas Transplant Committee. Dr. Chavers is Co-editor of the American Journal of Kidney Diseases. She has been published numerous times in a variety of journals and books. Her areas of research and special interest include cardiovascular disease in children with kidney disease, pediatric kidney transplant outcomes, and diabetic nephropathy. Dr. Chavers has received grants from the Department of Health and Human Services for the National Health and Nutrition Survey IV (NHANES) and the United States Renal Data System.

Alfred K. Cheung, MD, is a Professor of Medicine in the Division of Nephrology & Hypertension and the Executive Director of the Dialysis Program at the University of Utah. He received his Nephrology fellowship training at the University of California, San Diego, under the research mentorship of Dr. Lee Henderson. His research interest has focused on chronic kidney disease and HD. In addition to serving as a member of the editorial board of several journals, he has served as an Associate Editor of the four editions of the National Kidney Foundation Primer on Kidney Diseases, and the Journal of American Society of Nephrology. Dr. Cheung is the principle investigator of grants from the National Institutes of Health and the Department of Veterans Affairs for the study of novel strategies to prevent vascular access stenosis. He is also the Chair of the Kidney Disease Research Consortium, which was formed in 2003 for the purpose of performing multicenter studies related to chronic kidney disease and dialysis. In the last 15 years, he has served on a number of committees in the National Kidney Foundation and the American Society of Nephrology, and has lectured frequently in national meetings of those organizations. He is currently the Chair of the D-Subcommittee in the National Institute of Diabetes and Digestive and Kidney Diseases for grant reviews. Dr. Cheung has co-authored over 100 papers and book chapters. He is actively involved in the care of patients with chronic kidney disease and the training of fellows for clinical nephrology and research.

David N. Churchill MSc, MD, FRCPC, FACP, is Professor of Medicine in the Faculty of Health Sciences at McMaster University, Hamilton, Ontario. He was the Director of the Division of Nephrology from 1989–1999. Currently, he has a cross-appointment in the Department of Clinical Epidemiology and Biostatistics at McMaster University. He has been a member of the Scientific Advisory Board of the Kidney Foundation of Canada for 3 terms since 1987 and the National Kidney Foundation Research Review Committee since 2002. From 1995–1998, he was Chair of the ISPD Committee on International Studies. Dr. Churchill was the Vice-Chair of the original DOQI Peritoneal Dialysis Work Group and is currently a member of the KDOQI Advisory Board. He was also the Chair for the Canadian Society of Nephrology Committee on Clinical Practice Guidelines from 2000–2003. He is an Associate Editor for the Journal of the American Society of Nephrology and is a member of the Editorial Boards for Nephrology, Dialysis and Transplantation; Peritoneal Dialysis International and the Hong Kong Journal of Nephrology. Dr. Churchill’s research interests include adequacy of dialysis (Co-Principal Investigator for the CANUSA group), anemia of renal disease, quality of life in ESRD, vascular access and economic analysis. He has 140 peer-reviewed publications and 9 book chapters. He is the Chair of the Amgen Canada Scientific Advisory Board and has received research funding from Amgen. He has also been a consultant for Genzyme Corporation.

Jordi Goldstein-Fuchs, DSc, RD, is Clinical Assistant Professor at the University of Nevada School of Medicine, Department of Internal Medicine and is completing a second term as Editor-in-Chief of the Journal of Renal Nutrition. She also works with DaVita, Inc. as a researcher and clinical dietitian in Reno, NV. Dr. Goldstein first became interested in kidney disease while studying for her Master’s degree at the MGH Institute of Health Professions. Her research thesis was in the area of urea kinetic modeling. The resulting publication was awarded the Mary P. Huddleson Award by the American Dietetic Association. After working as a renal dietitian for several years, Dr. Goldstein returned to graduate school and received her Doctor of Science degree in Nutritional Sciences from Boston University. Her doctorate work was in the area of essential fatty acids and experimental kidney disease. She is the author or co-author of over 25 scientific publications and book chapters. Dr. Goldstein is now participating in research in chronic kidney disease and energy expenditure, and essential fatty acids with the Comprehensive Dialysis Study. She is the recipient of the 2003 Service Award from the National Kidney Foundation Council on Renal Nutrition. She is a member of several nutrition and kidney societies including the International Society of Renal Nutrition & Metabolism, the Council on Renal Nutrition of the National Kidney Foundation, and the American Dietetic Association. Dr. Goldstein is a reviewer for several nutrition and nephrology journals.

Charles A. Herzog, MD, is Director of the Cardiovascular Studies Center, United States Renal Data System. He has been a cardiologist at Hennepin County Medical Center (HCMC) in Minneapolis and a University of Minnesota faculty member for 20 years; he recently became Professor of Medicine at the University of Minnesota. Since 1985 he has been the cardiology consultant to the ESRD program at HCMC (dialysis and renal transplantation). He founded the program in interventional cardiology and served as the director of the cardiac catheterization laboratory at HCMC from 1985 to 1991. Since 1997 he has been the director of the cardiac ultrasound laboratory at HCMC. Dr. Herzog is a Fellow of the American College of Cardiology. His areas of research or special interest include cardiac disease and ESRD and echocardiography. Dr. Herzog has received research support from Amgen, Astra-Zeneca, Medtronic, and the National Institutes of Health (NIDDK). He has been a consultant for Amgen, Bayer Ag (Chairman, Critical Event Committee, CHORUS trial), Camtel Medical (Minntech), Ortho-Biotech/Johnson & Johnson (Critical Event Committee, CHOIR trial), Guidant, and NIH (member DSMB, FAVORIT trial). He has received lecture honoraria from Bayer, Ortho-Biotech/Johnson & Johnson, and First Nuclear. He recently was appointed trustee of the Roche Foundation for Anemia Research (ROFAR).

William Henrich, MD, is the Theodore E. Woodward Professor and Chairman of Medicine at the University of Maryland School of Medicine. He also serves as Physician-in-Chief of the University of Maryland Medical Center. Dr. Henrich joined the Department as Chairman in February of 1999. A nephrologist with special interests in end stage renal disease and analgesic-related renal disease, he received his M.D. from the Baylor College of Medicine in Houston, Texas. He then served his internship and residency in medicine at the University of Oregon Medical School Hospitals and Clinics, and fellowship in renal diseases at the University of Colorado Medical School. He is the author or co-author of over 200 scientific publications. He is also the editor of the popular dialysis textbook The Principles and Practice of Dialysis, just released in its third edition. Dr. Henrich has maintained an active investigative interest in heart disease in dialysis patients, hemodynamic stability during dialysis, analgesic nephropathy and the intrarenal renin-angiotensin system. He currently leads a NIH-sponsored multicenter study of the effect of analgesics on the kidney and has a leadership role as Co-Chair in a NIH multicenter trial on renal artery stenosis. Over the years he has been active in many professional societies including the American Society of Nephrology and National Kidney Foundation, and he is the recipient of the President’s and Distinguished Service Awards from the National Kidney Foundation. Dr. Henrich is an elected councilor of the American Society of Nephrology and is slated to serve as President of the Society in 2006–2007. He is a member of several prestigious scientific societies including the Association of American Physicians, American Society of Clinical Investigation, the International Society of Nephrology, and the American Clinical and Climatological Association. Dr. Henrich is a reviewer and editorial board member for several renal and internal medicine journals.

Karren King, MSW, ACSW, LCSW, is a kidney disease social work consultant. She served as president of the National Kidney Foundation’s (NKF) Council of Nephrology Social Workers (CNSW). She also served on the NKF Executive Committee and Board of Directors, as Chair of the NKF Patient Services Committee and on numerous other NKF committees both nationally and within the NKF affiliate. She was a member of the NKF’s Dialysis Outcomes Quality Initiative, HD Adequacy Work Group, as well as the Renal Physicians Association / American Society of Nephrology Workgroup that developed the Clinical Practice Guideline on Shared Decision Making in the Appropriate Initiation of and Withdrawal from Dialysis. She is a past member of the Life Options Rehabilitation Advisory Council, the Missouri Kidney Program Advisory Council and the Robert Wood Johnson Foundation, Promoting Excellence in End-of-Life Care, End Stage Renal Disease Peer Workgroup. She currently serves on the Executive Committee and Board of Directors of the Center for Practical Bioethics. She was also appointed by Secretary Donna Shalala to serve as a member of the Secretary of Health and Human Services Advisory Committee on Xenotransplantation. She is the editor of the NKF’s Family Focus patient newspaper. She also served on the editorial board of Geriatric Nephrology and Urology and was an Associate Editor of Advances in Renal Replacement Therapy. Ms. King is co-author of a chapter on kidney disease in the Encyclopedia of Disability and Rehabilitation. She has also published 19 papers and made over 60 presentations, both nationally and internationally, on the psychological and social aspects of kidney disease. She has been the recipient of the National CNSW Merit Award and its President’s Award, the National NKF’s Distinguished Service Award, the Chairman’s Award and the Martin Wagner Memorial Award, and was the first recipient of the University of Missouri School of Social Work Outstanding Alumni Award.

Florian Kronenberg, MD, is Professor of Genetic Epidemiology in the Department of Medical Genetics, Molecular and Clinical Pharmacology at the Innsbruck Medical University, Austria. He is Head of the Division of Genetic Epidemiology as well as of the Genotyping Unit of the “Gene Discovery Core Facility.” Dr. Kronenberg received his M.D. from the University of Innsbruck, Austria. After specializing in Medical Biology and Human Genetics he joined the University of Utah, Salt Lake City for a two-year research stay. He then headed the research unit “Genetic Epidemiology” at the Institute of Epidemiology at the GSF (National Research Center for Environment and Health, Munich, Germany) for two years. Recently he became Full Professor at the Innsbruck Medical University. Dr. Kronenberg served as principal investigator in several studies on genetic risk factors for atherosclerosis and disturbances in lipid metabolism especially in high-risk populations such as patients with kidney diseases or patients with peripheral arterial disease. He contributed several publications on the association of lipoprotein(a), the apolipoprotein(a) phenotype as well as lipoproteins not only in kidney patients but also in the general population. He has published about 75 peer-reviewed articles, and about 20 reviews and book chapters. Besides other awards he has been the recipient of the Bernd-Tersteegen Award of the German Dialysis Society as well as the Knoll William Harvey Prize. Dr. Kronenberg is on the Editorial Board of the Journal of Renal Nutrition and Experimental Gerontology and Current Women’s Health Review.

B. Sandra Miholics, RN, CNN, is an Independent Nephrology Nurse Consultant for Nephrology Outsourcing, providing Clinical Support Services to the nephrology community. Sandy received her nursing diploma from Charles E. Gregory School of Nursing, Perth Amboy, NJ. She has been in nephrology since 1967 and has served in most HD roles. She is an acute care dialysis nurse at Robert Wood Johnson University Hospital. She was Research and Vascular Access Coordinator at Dialysis Clinics Inc. in North Brunswick, NJ, coordinating clinical trials for the Vasca Lifesite Device, a new antibiotic, Cefazolin dosing in HD and a new method for rinsing dialyzers. She co-authored several articles on vascular access. In 1999, she wrote an abstract and did a survey on practice variations of heparinization for HD and the basis for the practices. It was published in the Nephrology Nursing Journal and presented as a poster at a National ANNA Symposium. Her interests have been urea kinetics, anticoagulation for HD, vascular access, nephrology specific quality assurance in hospital settings, regulatory support, and currently, infection control. Sandy has maintained membership in the American Nephrology Nurses Association (ANNA) since 1969. She founded the Garden State Chapter of ANNA in NJ and currently serves as its conference manager. While president of the chapter, she founded Reach Out for Children with Kidney Disease (ROCK), a fundraising project for pediatric kidney patients. She has also held various local, regional, and national positions with ANNA and does numerous presentations for nephrology professionals. As a volunteer she strives to promote the goals of ANNA within the workplace. She maintains membership in the American Nurses Association and the NJ State Nurses’ Association. Sandy is also a member of the Association for Professionals in Infection Control and Epidemiology (APIC). She is currently preparing for board certification to enable her to practice as an infection control professional.

Patricia L. Painter, PhD, is an Adjunct Associate Professor in the Department of Physiologic Nursing at the University of California, San Francisco. She also manages the Exercise Physiology Laboratory at UCSF. Dr. Painter has published many articles in journals such as Transplantation, Kidney International, Journal of Clinical Investigation, and Journal of Cardiovascular Physical Therapy. She was a member of the Board of Trustees for the American College of Sports Medicine and received a Distinguished Service Award from the National Kidney Foundation. Dr. Painter has also received grants from organizations such as Satellite Healthcare, Amgen, and the National Institute of Health. Her areas of interest are exercise physiology in end stage renal disease and after organ transplantation.

Rulan Parekh, MD, MS, is an Assistant Professor of Pediatrics and Internal Medicine at the Johns Hopkins University. She is a previous recipient of the American Kidney Fund clinical scientist fellowship and the Carl W. Gottshalk ASN Award for clinical investigation. In addition, Dr. Parekh has received research funding from the Child Health Center of the National Institutes of Health, NIDDK-NIH, the Thomas Wilson Sanitarium, and the National Kidney Foundation of Maryland, to study cardiovascular disease in children with end stage renal disease. She is also participating in an NIDDK-NIH sponsored multicenter collaborative study, the Family Investigation of Nephropathy in Diabetes (FIND). She is a scientific reviewer of grants for the National Kidney Foundation of Maryland, and the Clinical Scientist Selection Committee of the American Kidney Fund, and abstract reviewer for the American Society of Nephrology meetings. Dr. Parekh was also a work group member for the Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guidelines for Managing Dyslipidemias and is a current member of the KDOQI Advisory Board. She is a member of the advisory committee on obesity and minority children of the International Society on Hypertension in Blacks (ISHIB).

Mark S. Roberts, MD, MPP, is a practicing internist and Associate Professor of Medicine and Health Policy and Management and Chief of the Section of Decision Sciences and Clinical Systems Modeling in the Division of General Medicine at the University of Pittsburgh. A nationally recognized expert in modeling and decision sciences, he is an Associate Editor for Medical Decision Making, and is Chair of the Healthcare Technology and Decision Sciences study section of the Agency for Healthcare Research and Quality (AHRQ). He is a core faculty member of the Center for Research on Health Care, a multidisciplinary health services research center at the University of Pittsburgh, and Co-Director of the NHLBI-funded Clinical Research Training Program. He is funded as a principle investigator or co-investigator on multiple NIH grants from the HHLBI, NIDDK, NIGMS and the NSF. His research interests include the mathematical modeling of disease, cost effectiveness and decision analytic modeling, health services research and clinical information systems/quality improvement.

Catherine Stehman-Breen, MD, MS, received her medical degree from the University of Chicago in 1990. She received her residency and fellowship training at the University of Washington where she also received a Masters of Science degree in Epidemiology. She spent six years as a faculty member in the Division of Nephrology at the University of Washington. Her primary responsibilities included managing the Clinical Research Training Program and the development of the Epidemiology and Clinical Trials Research Program. Her research focused on bone and cardiovascular disease in renal disease patients. Dr. Stehman-Breen was also active in a variety of national programs including participation as a member of the Data Safety and Monitoring Board for the NIH sponsored Vascular Access Trials Consortium. She is currently an Associate Director of Clinical Research at Amgen.

Peter Stenvinkel, MD, PhD, is an Associate Professor at the Karolinska Institute, Stockholm, Sweden and a senior lecturer at the Karolinska University Hospital, Stockholm. He was a visiting Associate Professor at the University of California at Davis, California from 2000 to 2001. His main research interest is various aspects of inflammation, malnutrition and metabolism in ESRD patients. He has published about 110 original papers and contributed to 11 book chapters. Dr. Stenvinkel was a Baxter Extramural Grant awardee in 1996 and a Söderbergs Foundation awardee in 2003 from which he has received research grants. He has been a member of the Baxter Medical Advisory Board since 2002. He is a member of the Editorial Boards for the Journal of American Society of Nephrology and Nephrology Dialysis Transplantation. Dr. Stenvinkel is a member of American Society of Nephrology, International Society of Nephrology, Society of Nutrition and Metabolism, Swedish Society of Nephrology and Swedish Society of Hypertension. Dr. Stenvinkel is on the Advisory Board for Amgen from which he also receives a research grant. He has given about 70 invited lectures at various international meetings and congresses.

Ravinder Wali, MD, is Assistant Professor of Medicine in the Division of Nephrology at the University of Maryland School of Medicine. Dr. Wali received his M.D. from the Kashmir Medical College in India, and an MRCP from the Royal College of Physicians, Great Britain. He completed his internship and residency at the Georgetown Medical School and VA Medical Center in Washington, D.C., followed by a fellowship in Nephrology and Transplantation at the University of Maryland School of Medicine in July 1999. Following this he was offered a faculty position, which he accepted. His areas of interest are cardiovascular disease in patients with chronic kidney disease and following kidney transplantation, renal failure and chronic allograft nephropathy. His faculty positions include Staff Physician at the VA Baltimore, Assistant Instructor in the Division of Nephrology at UMSOM, and Registrar at the University of Glasgow School of Medicine, NHS Trust, Royal Infirmary, Glasgow, Great Britain. He has authored several scientific papers, and is a professional member of several scientific societies, including the American Society of Nephrology, the American Society of Transplantation and the National Kidney Foundation.

Miriam F. Weiss, MD, FACP, is Professor of Medicine at Case Western Reserve University. She is a member of the Division of Nephrology, Department of Medicine at University Hospitals of Cleveland, and founding Medical Director of the Home Dialysis Program at UH. As a clinical translational researcher, she has published on the management of complications of peritoneal dialysis. In the laboratory she is investigating the role of advanced glycation end products in uremia and in diabetic nephropathy.