Post date: December 10, 2012
Normal kidneys produce a hormone called prostaglandins that are used to protect the kidney from stress. Diclofenac and other non-steroidal anti-inflammatory drugs (NSAID's) cause the kidney to lose the capacity to make these protective hormones and over time, can result in progressive kidney damage. This damage may take years in some people but in others can occur after a single dose. NSAID's are very unpredictable drugs in the kidney.