CKD-EPI Creatinine Equation (2021)

Expressed as a single equation:

eGFRcr = 142 x min(Scr/κ, 1)α x max(Scr/κ, 1)-1.200 x 0.9938Age x 1.012 [if female]

where:

Scr = serum creatinine in mg/dL
κ = 0.7 (females) or 0.9 (males)
α = -0.241 (female) or -0.302 (male)
min(Scr/κ, 1) is the minimum of Scr/κ or 1.0
max(Scr/κ, 1) is the maximum of Scr/κ or 1.0
Age (years)

Assays

Creatinine is assayed using methods that are traceable to IDMS assigned NIST certified reference materials. To learn more, go to nkdep.nih.gov.

Clinical Use

  • Recommended method for estimating GFR in adults.
  • Designed for use with laboratory creatinine values that are standardized to IDMS.
  • Estimates GFR from serum creatinine, age, sex, and race.
  • More accurate than the MDRD Study equation, particularly in people with higher levels of GFR.
  • Based on the same four variables as the MDRD Study equation, but uses a 2-slope “spline” to model the relationship between estimated GFR and serum creatinine, and a different relationship for age, sex and race.
  • Some clinical laboratories are still reporting GFR estimates using the MDRD Study equation. The National Kidney Foundation has recommended that clinical laboratories should begin using the CKD-EPI equation to report estimated GFR in adults.
  • Developed in 2009 by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI).

References

  1. Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604-612.
  2. Levey AS, Stevens LA. Estimating GFR using the CKD Epidemiology Collaboration (CKD-EPI) creatinine equation: more accurate GFR estimates, lower CKD prevalence estimates, and better risk predictions. Am J Kidney Dis. 2010;55(4):622-627.
  3. Matsushita K, Selvin E, Bash LD, Astor BC, Coresh J. Risk implications of the new CKD Epidemiology Collaboration (CKD-EPI) equation compared with the MDRD Study equation for estimated GFR: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis. 2010;55(4):648-659.
  4. White SL, Polkinghorne KR, Atkins RC, Chadban SJ. Comparison of the prevalence and mortality risk of CKD in Australia using the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) Study GFR estimating equations: the AusDiab (Australian Diabetes, Obesity and Lifestyle) Study. Am J Kidney Dis. 2010;55(4):660-670.
  5. Becker BN, Vassalotti JA. A software upgrade: CKD testing in 2010. Am J Kidney Dis. 2009;55(1):8-10.
  6. Inker, AS. Frequently Asked Questions About GFR Estimates. New York: The National Kidney Foundation; 2011