You should contact your transplant team first before making any changes to generics. Switching to generic medicines has been done safely with transplant patients, if the team is aware of the change and the drug levels stay consistent.1 They will probably have you do more frequent blood tests to make sure that your levels of the medicines are stable.
Generally, studies on certain anti-rejection medicines (immunosuppresants), such as tacrolimus, have shown that patients can be converted from brand to generic safely and feasibly. However, in addition to drug concentrations, plasma creatinine levels may also be monitored.2,3
If you have any questions about your anti-rejection medicines, coverage, copays, and brand-vs-generic options, contact your transplant team and work with them to preserve your health and your transplanted organ.1 You should also talk to your pharmacy to make sure that they can consistently give you the same version of the medicine every month.
1. Tushla L, Medication Matters. https://www.kidney.org/transplantation/transaction/TC/summer10/TCsummer1...
2. González F, López R, Arriagada E, Carrasco R, Gallardo N, Lorca E. Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored. J Transplant. 2017;2017:5646858.
3. Rosenborg S, Nordström A, Almquist T, Wennberg L, Bárány P. Systematic conversion to generic tacrolimus in stable kidney transplant recipients. Clin Kidney J. 2014;7: 151-