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Kidney Diseases Trial Directory

About Clinical Trials for Kidney Diseases

Volunteering to participate in clinical trials helps researchers learn more about diseases and finding new ways to treat them. Although there are risks, clinical trial participation can be very rewarding because you can help learn more about today’s diseases while also helping discover treatments that may help people in the future.

Many people with kidney diseases want to know more about how to participate in clinical trials. This directory of trials features opportunities from partners who have requested the National Kidney Foundation to help bring these research opportunities to you. Other opportunities to participate in clinical research exist – ask your healthcare provider about other clinical trials happening in in your area.

APOL1 Gene Variation

  • APOL1 Program (Vertex Pharmaceuticals): Do you have symptoms of chronic kidney disease? If you are an individual of African ancestry with chronic kidney disease and high levels of protein in your urine, your condition may be caused by a gene variation, and a clinical research study may be an option for you. Visit apol1program.com to learn more information.

IgA Nephropathy (IgAN)

  • APPLAUSE-IgAN (Novartis): This is a Phase 3 global clinical trial that will look at the effects of an investigational drug, iptacopan (LNP023), in people with IgAN. The trial will study the effects of iptacopan (LNP023) on reducing inflammation and kidney damage in people with IgAN. https://www.iganclinicaltrial.com/
  • ARTEMIS-IGAN (Omeros Corporation): Do you have IgA Nephropathy and are interested in participating in a clinical trial? To see if you qualify, visit the ARTEMIS-IGAN clinical trial page.
  • BION-1301 (Chinook Therapeutics): Have you been diagnosed with Immunoglobulin A Nephropathy (IgAN)? If you have had a diagnosis of IgAN verified by a biopsy taken within the last 10 years, you may qualify for the BION-1301 clinical trial.
  • ORIGIN (Vera Therapeutics): Get to the root of your IgA Nephropathy (IgAN). Join the ORIGIN clinical research study, which is exploring an investigational medication for IgAN. Learn more at www.theoriginiganstudy.com.
  • RC18 (RemeGen): Phase 2 RC18 IgAN Study is seeking volunteers for participation in this study evaluating an investigational new drug to determine if it can treat IgAN. A clinical study using this investigational new drug in China showed potential benefit in treating IgAN by reducing urine protein. However, more clinical data is needed to further evaluate the effectiveness and safety of Telitacicept in IgAN patients. Patients who enroll in this study will be asked to participate for approximately 7 months. If you or a loved one have been diagnosed with IgA Nephropathy (IgAN) and are interested in exploring the option of clinical trial participation, send an email to RC18_IGANstudy@remegenbio.com with your name, phone and zip code. Your contact information will be shared with the nearest study site who can answer all of your questions and help to determine if you are eligible to participate in the study. For additional information, visit our page on ClinicalTrials.gov.

Kidney Donation and Transplantation

  • COVID-19 Registry (Invivyd): If you are aged 18 to 65, immunocompromised, and received the bivalent (Omicron) vaccine booster within the past 8 weeks, or you plan to in the next few months, you may be eligible to participate in a Registry. As part of the Registry, you will have the opportunity to have your antibody levels (titer) checked at a laboratory close to you, at no charge. Participation in the Registry along with your titer results will help determine if you might qualify for a COVID-19 Prevention study evaluating an investigational monoclonal antibody. For additional information about the Registry, visit the trial website to learn more.
  • FREEDOM-1 (Talaris Therapeutics): Are you planning on getting a transplant from a living donor? Learn more about a clinical trial that you might be eligible to participate in.

Membranous Nephropathy (MN)

  • REBOOT (NIH National Institute of Allergy and Infectious Diseases): The Immune Tolerance Network (ITN) is conducting a primary membranous nephropathy study, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID). For more information or if you are interested in participating in this study, please visit the REBOOT website.

Clinical Trial Databases

In addition to the opportunities listed above, several databases exist to help you find a clinical trial and learn how to get involved. Some examples are provided below. They can be accessed using the following links: 

  • CenterWatch: Use this listing service to find an industry-sponsored clinical trial that is currently seeking volunteers.
  • Clinicaltrials.gov: Search this database of publicly and privately supported clinical studies around the world
  • National Heart, Lung, and Blood Institute (NHLBI) Clinical Trials: Search this database of studies for diseases and conditions sponsored by the NHLBI to see if you or a loved one is eligible.
  • ResearchMatch.org: Create a volunteer profile for yourself or for someone else as their parent or guardian. This NIH-funded resource is a free, secure registry that will keep you informed of clinical research studies that need volunteers matching your profile.
  • Antidote: Let's find cures together. Click start in the box below and answer a series of questions to see if there is a clinical trial that may be a match for you. The link in the box below will open a new browser window or tab so make sure you have enabled pop-ups.

The National Kidney Foundation shares these clinical trial listings to help advance research for kidney diseases. The NKF does not endorse any specific commercial product studied or used in any of these trials. Each trial has different eligibility criteria. For more specific information, visit the website for the trial.

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