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I cannot give you medical advice without knowing your complete medical history and performing a physical examination. Patients who have kidney disease and Type 2 diabetes mellitus do have an increased risk of complications when they take Metformin (Glucophage), but the risk versus benefit can only be determined by your physician.
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An estimated glomerular filtration rate (eGFR) of 88 milliliters per minute per 1.73 meters squared in a woman of 51 years is normal.
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An estimated glomerular filtration rate (eGFR) of 48 and 42 are not much different from each other and would be within the range of laboratory variation. For only having one half of a kidney, this is a very good eGFR.
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An estimated glomerular filtration rate (eGFR) of 54 milliliters per minute per 1.73 meters squared is a normal eGFR for a transplanted single kidney.
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There is always a variability to the estimated glomerular filtration rate (eGFR) number.  It may vary slightly up and down from time to time, but the general trend in all forms of chronic kidney disease is for that number to gradually decline at a rate that may be between 1 and 20 milliliters per minute per 1.73 meters squared...
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For someone with mild chronic kidney disease (CKD) with an estimated glomerular filtration rate (eGFR) of 54 milliliters per minute per 1.73 meters squared, I recommend a low salt diet such as the DASH diet. This diet can be found at: http://www.nhlbi.nih.gov/health/public/heart/hbp/dash/new_dash.pdf I also recommend maintaining a healthy weight, exercising...
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An estimated glomerular filtration rate (eGFR) of 48 milliliters per minute per 1.73 meters squared, means that you may have Stage 3 chronic kidney disease. It is not end stage kidney disease. You should follow the advice of your doctor, make sure your blood pressure is well controlled, follow a low salt diet, and maintain a healthy lifestyle with exercise and weight control. It is not commonly possible to improve the eGFR if this is CKD, but...
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I don't know. You should have it retested in 3 months to see. Most of the time it will recover.
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This degree of variability of the estimated glomerular filtration rate (eGFR) is unusual.  It is possible that a laboratory error was made.  Repeated testing is the only way to know for sure what the actual number may be.
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An estimated glomerular filtration rate (eGFR) of greater than 60 milliliters per minute per 1.73 meters squared is normal.
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